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Abstract #3223

MOBILE allows a follow-up of brain oxygen variations during a 100% 02 breathing

Florence Colliez 1 , Julie Magat 1 , Marta M Safronova 2 , Bndicte F Jordan 1 , Thierry Duprez 3 , and Bernard Gallez 1

1 Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium, 2 Service de Radiologie, Cliniques universitaires Saint-Luc, Brussels, Belgium, 3 Department of Radiology and Medical Imaging, Cliniques universitaires Saint-Luc, Brussels, Belgium

There is a critical need for dynamic and noninvasive methods able to monitor brain oxygenation in clinical practice. Variations in T1 and T2* are potentially valuable MRI tools to detect changes in tumor oxygenation. We hereby (i) test the ability of MOBILE, a method of oxygenation mapping based on the changes in the relaxation properties of the tissue lipids, to map brain oxygenation in brain and cerebellum (ii) evaluate its capability to follow an increase in oxygenation on healthy volunteers submitted to a 100% O2 breathing (iii) and compare sensitivities of the MOBILE and Oxygen enhanced MRI techniques.

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