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Abstract #3222

Thermal Responses of MRI Contrasts in ex vivo Tumor and Muscle Tissue

Matthew Tarasek 1 , Oguz Akin 2 , Jeannette Roberts 3 , Thomas Foo 1 , and Desmond Yeo 1

1 Diagnostics & Biomedical Technologies, GE Global Research, Niskayuna, NY, United States, 2 Radiology, Memorial Sloan Kettering Cancer Center, NY, United States, 3 Biomedical Imaging & Physiology, GE Global Research, Niskayuna, NY, United States

Longitudinal relaxation time (T1), and transverse relaxation time (T2) are examples of imaging parameters that change with temperature. It is challenging to use these descriptors to measure temperature in vivo because the way they change is very tissue dependant. Here we use T1, and T2 to determine salient characteristics of ex vivo rat breast adenocarcinoma and rat prostate carcinoma tumors and their surrounding muscle tissues at steady-state temperatures from ~0C to 22C. Findings indicate a link to improved MR imaging visualization or characterization of tumors with heat-induced T1/T2 relaxation contrast types.

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