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Abstract #3210

Real-time motion correction for T1rho mapping of human brain

Ovidiu Cristian Andronesi 1 , Dylan M. Tisdall 1 , and Andre J. van der Kouwe 1

1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

T1 relaxation in the rotating frame (T1rho) is sensitive to molecular dynamics of water molecules interacting with macromolecules and has been shown to be a valuable imaging biomarker in stroke, neurodegenerative diseases (Alzheimers Disease, Parkinson Disease), cancer, liver cirrhosis and cartilage damage. Mapping of T1rho relaxation constant requires the acquisition of a time series of images with increasing rotating frame relaxation weighting. Perfect alignment of the images in the time series is critical for the accurate fitting of the T1rho constant. Because of large changes in the contrast among images acquired at different preparation (weighting) times, postprocessing motion correction algorithms have difficulties to accurately coregister serial volumes and may introduce false displacements. Here, we show that real-time motion correction improves the quality of T1rho mapping when subjects move.

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