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Abstract #3209

B1+ and B0 Corrected High Resolution Whole Brain T1-mapping at High Field in a Clinically Acceptable Scan Time

Govind Nair 1 , Qi Duan 1 , Daniel S Reich 1 , and Souheil Inati 2

1 NINDS, National Institutes of Health, Bethesda, MD, United States, 2 NIMH, National Institutes of Health, Bethesda, MD, United States

B1-mapping techniques are seldom applied to T1-mapping of the human brain at high field strengths due to the high SAR resulting in long scan times. Background-field-corrected Bloch-Siegert B1-mapping scheme is used here for whole-brain T1-mapping at 1 mm isotropic resolution on a 7T scanner. The total scan time was less than 30 minutes. The corrected T1 map was uniform and had a distinct bimodal distribution with peaks at 1350 and 1950 ms, and repeat calculation at non-optimal shimming yielded an average change of 0.1 0.1%. This technique is being applied in quantitative lesion-evolution study in multiple sclerosis.

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