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Abstract #3206

Optimal Unbiased Steady-State Relaxometry with Phase-Cycled Variable Flip Angle (PCVFA) by Automatic Computation of the Cramr-Rao Lower Bound

Jason Su 1,2 and Brian Rutt 2

1 Electrical Engineering, Stanford University, Stanford, CA, United States, 2 Radiology, Stanford University, Stanford, CA, United States

An open source computational framework that calculates the CRLB for arbitrary signal equations to machine precision with minimal effort is developed and applied to the analysis of steady-state relaxometry with the SPGR and bSSFP pulse sequences. The unbiased protocol that achieves the highest precision efficiency estimate of T1 and T2 is found allowing the free variables: flip angle, phase cycle, and acquisition time fraction. The optimum PCVFA protocol consists only of 0 and π-phase-cycled bSSFP at 4 flip angles. This provides over a factor of 2.1x gain in efficiency for simulated WM and GM compared to previous related DESPOT2 protocols.

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