Abstract #3206
Optimal Unbiased Steady-State Relaxometry with Phase-Cycled Variable Flip Angle (PCVFA) by Automatic Computation of the Cramr-Rao Lower Bound
Jason Su 1,2 and Brian Rutt 2
1
Electrical Engineering, Stanford University,
Stanford, CA, United States,
2
Radiology,
Stanford University, Stanford, CA, United States
An open source computational framework that calculates
the CRLB for arbitrary signal equations to machine
precision with minimal effort is developed and applied
to the analysis of steady-state relaxometry with the
SPGR and bSSFP pulse sequences. The unbiased protocol
that achieves the highest precision efficiency estimate
of T1 and T2 is found allowing the free variables: flip
angle, phase cycle, and acquisition time fraction. The
optimum PCVFA protocol consists only of 0 and
π-phase-cycled bSSFP at 4 flip angles. This provides
over a factor of 2.1x gain in efficiency for simulated
WM and GM compared to previous related DESPOT2
protocols.
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