Meeting Banner
Abstract #3205

Rapid Dynamic Temperature / T 1 / T 2 * Assessment: A Method With Potential For Monitoring Drug Delivery.

Cyril Lorenzato 1 , Chris Oerlemans 1 , Baudouin Denis de Senneville 1,2 , Chrit Moonen 1 , and Clemens Bos 1

1 Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands, 2 UMR 5251 CNRS / Universit Bordeaux 1 / INRIA, Institut de Mathmatiques de Bordeaux, Talence, France

Thermosensitive liposomes (TSL) can be prepared to contain drugs as well as paramagnetic MR-contrast agents. This would allow heat induced local drug release, while detecting the release by imaging relaxivity changes. A method is presented to measure T 1 , T 2 * and temperature simultaneously and is applied to monitor release from gadolinium containing TSL during heating. The results indicated the need to correct for temperature related apparent proton density changes in the T1 measurements. The method will be an aid to monitor the release of MR-contrast agents from TSL in local drug delivery studies, as a correlate of drug release.

This abstract and the presentation materials are available to members only; a login is required.

Join Here