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Abstract #3203

Imaging T 1 , T 2 and proton density with minimum possible acquisitions

Guan Wang 1,2 , Abdel-Monem M. El-Sharkawy 2 , and Paul A. Bottomley 1,2

1 Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2 Russell H. Morgan Dept. of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States

T 1 , T 2 and proton density contain almost all of the information that MRI routinely uses in clinical diagnosis and research, but are seldom imaged directly. Moreover, measurements depend critically on B 1 -field homogeneity making field mapping essential at higher field strengths. Here, a novel method that measures T 1 , T 2 , PD and B 1 with only four acquisitionsthe minimum possibleis presented. This Tri-FA method encodes T 1 with three varied flip-angles, and T 2 via long 0 BIR-4 pre-pulses instead of spin-echoes. 2D and 3D Tri-FA imaging is demonstrated in vitro and in human brain studies at 3 Tesla.

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