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Abstract #3199

Refocusing Flip Angle Map Constrained Fitting for Indirect Echo Compensated T2 Mapping

Chuan Huang 1 , Maria I Altbach 2 , Quanzheng Li 1 , Xiaomeng Zhang 1 , and Georges El Fakhri 1

1 Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Medical Imaging, The University of Arizona, Tucson, AZ, United States

multiple spin-echo is generally used due for T2 mapping to the long acquisition time required by single spin-echo strategies. However, because of pulse imperfection, the signal acquired by MSE sequence is generally contaminated by indirect echoes. Several groups have investigated T2 fitting techniques incorporating the indirect echoes into the signal model. One common aspect of these model-based indirect echo compensated T2 estimation techniques is that the flip angles of the refocusing pulses are also being fitted to the acquired TE images for each pixel along with T2 values. However, due to the non-convex nature of the cost function in the fitting, there is an ambiguity issue for the refocusing flip angles. Breikreutz et al proposed to use separately acquired rFA map to improve the accuracy. However, the additional acquisition time for rFA mapping is not desirable, and the approach also suffers from subject motion between these two acquisitions. In this work, we propose an iterative refocusing flip angle map constrained T2 decay model fitting technique with indirect echo compensated to solve the ambiguity problem without additional acquisition.

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