Abstract #3164
Imaging brain microenvironments of glial restricted precursor cells in injectable growth-factor supplemented hydrogels using CEST MRI
Kannie WY Chan 1,2 , Antje Arnold 1,3 , Ali Fatemi 4 , Michael Porambo 4 , Peter CM van Zjil 1,2 , Jeff WM Bulte 1,3 , Piotr Walczak 1,3 , and Michael T McMahon 1,2
1
Radiology, Johns Hopkins University School
of Medicine, Baltimore, MD, United States,
2
Kennedy
Krieger Institute, Baltimore, MD, United States,
3
Institute
for Cell Engineering, MD, United States,
4
Neurology
and Developmental Medicine, Kennedy Krieger Institute,
Baltimore, MD, United States
Cell therapy has shown promise for treating neurological
disorders, e.g. stroke, spinal cord injury and multiple
sclerosis. Primary challenges include protection and
support of cell grafts after transplantation, along with
methods to determine cell functionality. These would be
important in refinement of treatments, allowing early
evaluation of the success of cell therapy for restoring
the lost function. Hydrogels have been used to protect
and support therapeutic cells in such therapies, here,
we show that CEST MRI allow imaging of the
microenvironments, including pH, for specific injectable
hydrogels suited for glial restricted precursor cells (GRPs).
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