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Abstract #3145

Multi-Component Fitting of T 2 * Relaxation in White Matter at 3 and 7 Tesla

Erika P. Raven 1 , Peter van Gelderen 2 , Xiaozhen Li 2 , Jacco A. de Zwart 2 , John VanMeter 3,4 , and Jeff H. Duyn 2

1 Neuroscience, Georgetown University, Washington, DC, United States, 2 Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States, 3 Neurology, Georgetown University, Washington, DC, United States, 4 Georgetown Center for Functional and Molecular Imaging, Washington, DC, United States

Previous studies have demonstrated separation of cellular compartments by utilizing large, local frequency shifts (Δf) and increased T 2 * relaxation at high magnetic field strength (7 T). This abstract examines the reproducibility of a multi-component fitting model at 7 T, while also investigating the feasibility of this method at 3 T. Our findings suggest the possibility of separating cellular specific contributions in white matter at both 3 and 7 T. Quantification of cellular compartments, importantly the myelin-water fraction, has important implications for the study of normal aging and disease.

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