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Abstract #3134

MRI evaluation of the relationship between R 2 , R 2 *, and tissue iron in the human basal ganglia

Joanna Collingwood 1,2 , Mary Finnegan 1 , Zobair Arya 3 , Jean-Pierre Hagen 1 , Saherabanu Chen 1 , Alimul Chowdhury 4 , Sarah Wayte 5 , Eddie Ngandwe 5 , Naomi Visanji 6 , Jon Dobson 7 , Penny Gowland 8 , Lili-Naz Hazrati 9 , and Charles Hutchinson 5,10

1 School of Engineering, University of Warwick, Coventry, West Midlands, United Kingdom, 2 Materials Science and Engineering, University of Florida, Gainesville, Florida, United States, 3 Department of Physics, University of Warwick, West Midlands, United Kingdom, 4 School of Psychology, University of Birmingham, West Midlands, United Kingdom, 5 University Hospitals Coventry and Warwickshire, West Midlands, United Kingdom, 6 Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Ontario, Canada, 7 J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Florida, United States, 8 School of Physics & Astronomy, University of Nottingham, Nottinghamshire, United Kingdom, 9 Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Ontario, Canada, 10 Warwick Medical School, University of Warwick, West Midlands, United Kingdom

R2 and R2* were determined for primary regions in the basal ganglia. Ten adult volunteers were measured at 3.0T and 1.5T on clinical platforms; R2*, R2, and the field-dependent R2 increase (FDRI) were compared with previously reported iron concentrations for the same regions. A set of post-mortem tissues were measured at 9.4T using a Bruker MicWB40; relationships between iron, R2, and R2* were directly evaluated by mapping tissue iron distribution with synchrotron X-ray fluorescence, enabling spatial correlation with MRI maps. These data indicate that at 9.4T the linear relationship between both R2 and R2*, and tissue iron concentration, is preserved.

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