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Abstract #3118

Simultaneous intracranial EEG-fMRI of a seizure

David Carmichael 1 , Umair J Chaudhary 2 , Rachel C Thornton 2 , Roman Rodionov 2 , Serge Vulliemoz 3 , Andrew W McEvoy 4 , Beate Diehl 2 , Matthew C Walker 2 , John S Duncan 2 , and Louis Lemieux 2

1 Imaging and Biophysics, UCL Institute of Child Health, London, United Kingdom, 2 UCL Institute of Neurology, London, United Kingdom, 3 EEG and Epilepsy Unit, University Hospital and Functional Brain Mapping Lab, Geneva, Switzerland, 4 Victor Horsley Department of Surgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom

We used the recently developed method of combined intracranial EEG and fMRI (icEEG-fMRI) in a patient with epilepsy who had a focal electrographic seizure during scanning. We used an expert visually coded model and a quantitative model of spectral dynamics during the seizure obtained by frequency transformation followed by convolution by a haemodynamic response function and principle component analysis (PCA). Both models gave a similar widespread network of changes including in the right temporal lobe where the seizure onset was recorded. The quantitative model had greater statistical power and included a cluster proximal to the electrode that recorded seizure onset.

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