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Abstract #3103

A breathing apparatus providing improved control of FiO2 and FiCO2 for calibrated fMRI

Felipe B Tancredi 1,2 , Isabelle Lajoie 1,2 , and Richard D Hoge 1,2

1 Institut de gnie biomdical, Universit de Montral, Montreal, Quebec, Canada, 2 Centre de recherche de l'IUGM, Montreal, Quebec, Canada

Respiratory manipulations inducing global changes in CBF and BOLD have been used to measure cerebral vascular reactivity and metabolism. Respiratory stimulus is commonly achieved by delivering predetermined concentrations of gases for inspiration, yielding end-tidal (ET) values that are used for retrospective normalization of the fMRI signal. The simplest method has been to administer O2/CO2 mixtures through low-cost oxygen masks. However, control over the administered dose have been difficult using this approach which hampers reproducibility of ET responses. We have designed a breathing apparatus allowing precise adjustments in FiO2/FiCO2 and good intra-subject reproducibility of ET levels.

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