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Abstract #3102

Reproducibility of M, CMRO2 and OEF measurements using QUO2 MRI and dual-echo pCASL

Isabelle Lajoie 1 , Felipe B Tancredi 1 , Danny J Wang 2 , and Richard D Hoge 1

1 Centre de recherche de l'IUGM, Montreal, Quebec, Canada, 2 Neurology, University of California, Los Angeles, CA, United States

We describe here an optimized protocol for the acquisition and processing of MRI data for the quantification of oxidative metabolism (CMRO2) using the QUantitativeO2 (QUO2) method with fixed concentrations of respirator gases and a DE-pCASL sequence. We assessed the reproducibility of the method and obtained respective inter-session coefficients of variation (CV) of 10%, 15%, and 17% for M (extrapolated maximum BOLD signal), OEF0 (Oxygen Extraction Fraction) and CMRO20. In future work, we will extend the protocol to MRI scanners from multiple scanner vendors and verify that equivalent results can be obtained at different scanning sites.

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