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Abstract #3100

Contributions of excitatory and inhibitory neural activities to BOLD and CBV fMRI

Alexander Poplawsky 1 , Mitsuhiro Fukuda 1 , Xiaopeng Zong 2 , and Seong-Gi Kim 1,3

1 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, United States, 3 Biological Sciences, Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), SKKU, Suwon, Korea

We used high-resolution fMRI in the olfactory bulb model to determine whether inhibitory neurons contribute to the hemodynamic response. Odor and micro-stimulation of the anterior commissure (AC) were used to preferentially evoke excitatory and inhibitory processes, respectively. For both BOLD and CBV fMRI, we measured hemodynamic responses in bulb layers corresponding to inhibitory neuron activity. Of particular interest, the combined odor plus AC stimulations revealed a relative increase in fMRI changes at layers corresponding to the net increase in total synaptic activity (excitatory + inhibitory). Our data show that excitatory and inhibitory activities contribute to hemodynamic responses in the bulb.

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