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Abstract #3099

The Effect of Dissolved Oxygen on Relaxation Rates of Blood Plasma

Yuhan Ma 1 , Avery J.L. Berman 1 , and G. Bruce Pike 1,2

1 McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 2 Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, Alberta, Canada

We investigated the effect of dissolved oxygen in arterial blood plasma on BOLD signal during the hyperoxia calibrated BOLD method by examining the relaxation rates of bovine blood plasma under various partial pressures of oxygen. The R 1 of plasma linearly increases with oxygen concentration, whereas R 2 and R 2 * are unaffected. Therefore, dissolved oxygen in arterial plasma should not induce significant BOLD contrast through R 2 and R 2 * effects. This study verifies that under hyperoxia, BOLD signal contrast arises from dHb in venous and capillary blood - the fundamental basis of the calibrated BOLD method - and not dissolved oxygen in arteries.

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