Abstract #3033
Phenotyping assay of neuropathic pain models using selective stimulation for peripheral nerve fibers
Yuji Komaki 1,2 , Keigo Hikishima 1,2 , Shinsuke Shibata 1 , Masaya Nakamura 1 , and Hideyuki Okano 1
1
Keio University, Shinjuku, Tokyo, Japan,
2
Central
Institute for Experimental Animals, Kawasaki, Kanagawa,
Japan
For better understanding of the neuropathic pain, one of
the crucial tasks is to develop the evaluation of the
pain with high objectivity. The neuropathic pain model
with surgical manipulation and with inheritable genetic
modification was compared with intact mice using tactile
like stimulus for peripheral nerve fibers. The resulting
analysis showed, for intact mice, the only S1 was
activated. In comparison with intact model, models of
neuropathic pain showed the significantly high BOLD
activities in ACC and thalamus. Therefore abnormally
connection of A
-fiber
was considered as a possible cause of neuropathic pain.
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