Abstract #3032
Study of the linearity in BOLD response in spinal fMRI
Michela Fratini 1 , Marta Moraschi 1,2 , Bruno Maraviglia 1 , Federico Giove 1,3 , Paul Summers 4 , Stefania Favilla 4 , and Carlo Adolfo Porro 4
1
Fermi Center, Rome, Rome, Italy,
2
Fondazione
Santa Lucia, Rome, Italy,
3
Dipartimento
di Fisica, Sapienza Universita` di Roma, Rome, Italy,
4
Dipartimento
di Scienze Biomediche, Univ. Modena e Reggio Emilia,
Modena, Italy
Spinal cord fMRI may be of immediate application in
neuroradiology, and in particular for the assessment and
follow-up of spinal injuries, pain, and
neurodegenerative diseases. However, the exact features
of functional response, and the biophysical origin of
the signal, are still unclear. In this framework, we
parametrically studied the connection between
stimulation strength and functional response using
controlled motor task (isometric task). We observe a
strong parametric dependence of functional response in
the spinal cord on the stimulation strength. Such a
dependence confirms the physiological origin of the
response, and is of great help in model-based fMRI
inference.
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