Meeting Banner
Abstract #3002

Inhomogeneity of signal intensity is a potential source for BOLD signal inaccuracy in ultra-high field fMRI

Satomi Higuchi 1 , Ikuko Uwano 1 , Kohsuke Kudo 1,2 , Jonathan Goodwin 1,2 , Fumio Yamashita 1 , Kenji Ito 1 , Taisuke Harada 1,2 , and Makoto Sasaki 1

1 Division of Ultrahigh Field MRI, Iwate Medical University, Yahaba, Iwate, Japan, 2 Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan

Ultra-high field MRI offers potential benefit for functional imaging due to enhanced BOLD effect. However, signal intensity inhomogeneity is severe at ultrahigh field MRI. Therefore, we tested the effect of signal inhomogeneity correction for detection of BOLD signal changes, and found that brain regions affected by coil insensitivity and susceptibility artefact showed underestimated BOLD signal, whereas regions closest to the surface coil such as visual cortex, showed overestimated BOLD signal. These results highlight the need for pre-processing of ultra-high field fMRI data to correct for inhomogeneity of signal intensity, prior to model estimation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here