Abstract #3002
Inhomogeneity of signal intensity is a potential source for BOLD signal inaccuracy in ultra-high field fMRI
Satomi Higuchi 1 , Ikuko Uwano 1 , Kohsuke Kudo 1,2 , Jonathan Goodwin 1,2 , Fumio Yamashita 1 , Kenji Ito 1 , Taisuke Harada 1,2 , and Makoto Sasaki 1
1
Division of Ultrahigh Field MRI, Iwate
Medical University, Yahaba, Iwate, Japan,
2
Department
of Diagnostic and Interventional Radiology, Hokkaido
University Hospital, Sapporo, Hokkaido, Japan
Ultra-high field MRI offers potential benefit for
functional imaging due to enhanced BOLD effect. However,
signal intensity inhomogeneity is severe at ultrahigh
field MRI. Therefore, we tested the effect of signal
inhomogeneity correction for detection of BOLD signal
changes, and found that brain regions affected by coil
insensitivity and susceptibility artefact showed
underestimated BOLD signal, whereas regions closest to
the surface coil such as visual cortex, showed
overestimated BOLD signal. These results highlight the
need for pre-processing of ultra-high field fMRI data to
correct for inhomogeneity of signal intensity, prior to
model estimation.
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