Abstract #3001
Inferring millisecond-scale functional connectivity from tissue microstructure
Alexandru V Avram 1 and Peter J Basser 1
1
Section on Tissue Biophysics and Biomimetics,
National Institutes of Health, Bethesda, MD, United
States
Quantifying voxel-averaged measures of cytoarchitecture
and tissue microstructure can provide valuable
information about functional organization of normal and
pathological brain tissue. In this study, we apply the
recently developed MAP-MRI framework to derive
microscopic descriptors of brain tissue and estimate
average axon diameters (AAD) in healthy volunteers. We
quantify AAD variations along white matter pathways and
discuss the feasibility of estimating conduction delays
along these fibers. Finally, we propose a new measure
for quantifying whole-brain functional connectivity at a
millisecond-scale called Latency Matrix.
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