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Abstract #3001

Inferring millisecond-scale functional connectivity from tissue microstructure

Alexandru V Avram 1 and Peter J Basser 1

1 Section on Tissue Biophysics and Biomimetics, National Institutes of Health, Bethesda, MD, United States

Quantifying voxel-averaged measures of cytoarchitecture and tissue microstructure can provide valuable information about functional organization of normal and pathological brain tissue. In this study, we apply the recently developed MAP-MRI framework to derive microscopic descriptors of brain tissue and estimate average axon diameters (AAD) in healthy volunteers. We quantify AAD variations along white matter pathways and discuss the feasibility of estimating conduction delays along these fibers. Finally, we propose a new measure for quantifying whole-brain functional connectivity at a millisecond-scale called Latency Matrix.

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