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Abstract #2966

Investigating Brain Energetics During and After Rat Whole Brain Occlusion

Jennifer M Taylor 1,2 , Xiao-Hong Zhu 2 , Yi Zhang 2 , and Wei Chen 1,2

1 Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 2 Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States

Multi-nuclei 1 H/ 31 P MRS and electrophysiology were applied to investigate rat brain energetics and neuronal activity changes during and after whole brain occlusion. PCr change was consistent among animals, while lactate trends split into 2 groups. ATP depletion was delayed following occlusion onset, before following the PCr trend, while pH and lactate were highly correlated. LFP bands showed different response dynamics from MRS measures, but exhibited recovery dynamics similar to ATP. LFP bursts, however, had a delayed recovery after reperfusion. These multimodal measures provide insight into the oxidative to nonoxidative phosphorylation transition and hint at underlying neuronal energy needs.

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