Abstract #2965
Cardioprotective Effects of mPTP Inhibition on Myocardial Ischemia/Reperfusion Injury in Perfused Rat Heart
Charlie Yi Wang 1,2 , Ya Chen 2,3 , and Xin Yu 1,4
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Case
Center for Imaging Research, Case Western Reserve
University, Cleveland, OH, United States,
3
Case
Western Reserve University, Cleveland, OH, United
States,
4
Radiology,
Case Western Reserve University, Cleveland, OH, United
States
The opening of the mitochondrial Permeability Transition
Pore (mPTP) during reperfusion is a critical step in the
pathogenesis of ischemia/reperfusion injury. mPTP
inhibition during reperfusion has been shown to be
cardioprotective. However, few studies have reported the
effect of mPTP inhibition on myocardial energetics
during IR. This study aimed at investigating whether
mPTP inhibition can normalize myocardial energetics
during reperfusion using 31P MR spectroscopy.
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