Abstract #2962
Neurochemical changes in scopolamine induced memory impairment in the mouse are detectable by in vivo magnetic resonance spectroscopy
Dong-Cheol Woo 1,2 and Robert E. Lenkinski 2
1
Biomedical Research Center, ASAN Institute
for Life Science, Asan Medical Center, Seoul, Seoul,
Korea,
2
Department
of Radiology, UT Southwestern Medical Center, Dallas,
Texas, United States
Our study is aimed at assessing neurochemical changes
caused by scopolamine (SCP) induced memory impairment
using proton in vivo MR spectroscopy. Adult male Swiss
albino mice (n=32) were used. Mice were divided into
four groups: SCP 0, 1, 3, and 5 (mg/kg). All mice
underwent 1H MR spectroscopy twice: at 30 min and 72
hours after the injection of a solution containing SCP.
Our results are in good agreement with previous
published reports that showed that SCP reduced choline
levels in the brain for about 2 hours. In vivo MR
spectroscopy is a non-invasive method with which to
evaluate the SCP induced memory impairment.
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