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Abstract #2962

Neurochemical changes in scopolamine induced memory impairment in the mouse are detectable by in vivo magnetic resonance spectroscopy

Dong-Cheol Woo 1,2 and Robert E. Lenkinski 2

1 Biomedical Research Center, ASAN Institute for Life Science, Asan Medical Center, Seoul, Seoul, Korea, 2 Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, United States

Our study is aimed at assessing neurochemical changes caused by scopolamine (SCP) induced memory impairment using proton in vivo MR spectroscopy. Adult male Swiss albino mice (n=32) were used. Mice were divided into four groups: SCP 0, 1, 3, and 5 (mg/kg). All mice underwent 1H MR spectroscopy twice: at 30 min and 72 hours after the injection of a solution containing SCP. Our results are in good agreement with previous published reports that showed that SCP reduced choline levels in the brain for about 2 hours. In vivo MR spectroscopy is a non-invasive method with which to evaluate the SCP induced memory impairment.

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