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Abstract #2961

In-vivo Longitudinal Relaxation Enhancements (LREs) of Central-Nervous-System Metabolites at 21.1 T upon Stroke

Noam Shemesh 1 , Jens T Rosenberg 2,3 , Jean-Nicolas Dumez 1 , Samuel Colles Grant 2,3 , and Lucio Frydman 1,2

1 Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2 National High Magnetic Field Laboratory, The Florida State University, Tallahassee, FL, United States, 3 Chemical & Biomedical Engineering, The Florida State University, Tallahassee, Florida, United States

Apparent metabolic T 1 s are important for quantification of MRS spectra in vivo. Longitudinal Relaxation Enhancements (LREs) upon band-selective excitation are well-known for large, slowly tumbling molecules. The surprising existence of LREs for small endogenous Central Nervous System metabolites was only recently reported ex vivo. Here, we aim at developing and applying a localized LRE-MRS sequence capable of detecting LREs in vivo, testing their potential as stroke biomarkers in the rat. At 21.1 T, the Cre resonance showed a statistically significant LRE effect upon spectrally-selective excitation, which was time-dependent. Lac apparent T 1 s also varied significantly upon stroke. These findings suggest LREs as novel potential stroke biomarkers.

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