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Abstract #2913

Localised in vivo measurement of GABA and glutamate in the rat brain at 4.7T

Stephen John Sawiak 1,2 , Bianca Jupp 3 , Daniele Caprioli 3 , T Adrian Carpenter 1 , and Jeffrey W Dalley 3

1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England, United Kingdom, 2 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, England, United Kingdom, 3 Department of Psychology, University of Cambridge, England, United Kingdom

The inhibitory neurotransmitter GABA plays a role in many psychiatric and neurological conditions. It is difficult to measure with in vivo 1H-MRS due to overlap with more abundant metabolites. The spectral-editing technique MEGAPRESS can be used to isolate the GABA signal. We demonstrate for the first time that this technique can be used in rats, and we give mean and variability values of the concentrations obtained in the ventral striatum.

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