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Abstract #2912

Feasibility of high throughput high performance 1 H MRS in baby-mice

Ivan Tkac 1 , Diana Wallin 2 , Michael K Georgieff 2 , and Raghu Rao 2

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States

The neurochemical profile of the mouse brain is changing extremely fast during the developmental period. Therefore, mice have to be scan at exactly the same age to avoid a bias caused by age dependent neurochemical changes. This study demonstrates that by optimizing the scanning protocol, high throughput 1 H MRS is feasible without compromising the data quality. The performance of this approach is demonstrated by using the anemia mouse model. An optimized scanning protocol enabled to scan 12 mice in a single study session.

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