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Abstract #2910

Optimal scan time for reproducible GABA measurements

Alexander R Craven 1 , Renate Grner 2,3 , Lars Ersland 4 , Gerard E Dwyer 1 , Maiken Kirkegaard Brix 1,2 , and Kenneth Hugdahl 1,5

1 Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 2 Department of Radiology, Haukeland University Hospital, Bergen, Norway, 3 Department of Physics and Technology, University of Bergen, Norway, 4 Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 5 Division of Psychiatry, Haukeland University Hospital, Bergen, Norway

Despite increasing usage of the MegaPRESS GABA-editing MRS sequence for measurement of GABA concentrations in the human brain, optimal values for some basic sequence parameters such as the number of repetitions (hence, scan time) have not been established in literature. The present investigation examines the effects of increasing scan time on reproducibility, leading to a recommendation of 256 averages (13 minutes) as a starting point. Furthermore, an upper limit on scan time to 20 minutes is recommended, whereafter cumulative disturbances begin to outweigh gains in signal quality.

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