Abstract #2909
Single-shot Lactate Editing using Foci-Laser and a Multiple Quantum Filter
Geoffrey S Payne 1 and Martin O Leach 1
1
Institute of Cancer Research and Royal
Marsden Hospital, Sutton, Surrey, United Kingdom
Lactate is an important potential cancer biomarker but
measurement is hampered by intense signals of
overlapping lipids, especially in the presence of
motion. Here a single-shot lactate sequence has been
conceived, implemented and evaluated on a Philips 3T
scanner. Based on the adiabatic semi-laser single-voxel
sequence, it uses FOCI RF-and-gradient pulses with large
bandwidth to overcome the chemical shift displacement
effect. In phantoms this flaser sequence more than
doubled the lactate signal of standard PRESS. MQF-flaser
included at TE/2 a 90
o
-180
o
-90
o
multiple-quantum
filter segment with -1:2 gradients. Lactate signals were
40% of flaser alone, while 1.3ppm lipid was totally
eliminated.
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