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Abstract #2909

Single-shot Lactate Editing using Foci-Laser and a Multiple Quantum Filter

Geoffrey S Payne 1 and Martin O Leach 1

1 Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Lactate is an important potential cancer biomarker but measurement is hampered by intense signals of overlapping lipids, especially in the presence of motion. Here a single-shot lactate sequence has been conceived, implemented and evaluated on a Philips 3T scanner. Based on the adiabatic semi-laser single-voxel sequence, it uses FOCI RF-and-gradient pulses with large bandwidth to overcome the chemical shift displacement effect. In phantoms this flaser sequence more than doubled the lactate signal of standard PRESS. MQF-flaser included at TE/2 a 90 o -180 o -90 o multiple-quantum filter segment with -1:2 gradients. Lactate signals were 40% of flaser alone, while 1.3ppm lipid was totally eliminated.

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