Abstract #2880
Investigating the reproducibility on the quantification of ^-aminobutyric acid (GABA) in visual cortex
Tzai-You Wu 1 , Chun-Hao Fang 1 , Yi-Ru Lin 1 , and Shang-Yueh Tsai 2
1
Electronic and Computer Engineering,
National Taiwan University of Science and Technology,
Taipei, Taiwan,
2
Graduate
Institute of Applied Physics, National Chengchi
University, Taipei, Taiwan
Quantification of ^-Aminobutyric acid (GABA) assessed
by MEGA-PRESS sequence need to be carefully investigated
because of its low concentration and can be sensitive to
editing efficiency. In this study the inter- and
intra-subject reproducibility of GABA quantified using
three quantification methods including integration,
fitting using two Gaussian shape and LCModel is
investigated. GABA spectra were collected from sixteen
healthy subjects in visual cortex. Results showed that
three quantification methods exhibit similar
intra-subject CV ranging from 11.1% to 15.3%. GABA+
quantified by direct integration is relatively stable
among three quantification methods, which implies simple
quantification strategy is sufficient for GABA spectra.
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