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Abstract #2879

Evaluation of 2D L-COSY to study lipid composition in mouse fatty liver at 7T

Dimitri MARTEL 1 , Jean-Baptiste Langlois 2 , Denis Friboulet 1 , Olivier Beuf 1 , and Hlne Ratiney 1

1 CREATIS; CNRS UMR 5220 ; INSERM U1044 ; Universit Lyon 1 ; INSA Lyon, Villeurbanne, France, 2 CERMEP-Imagerie du Vivant, Bron, France

Recent studies have demonstrated the ability of 1D MRS to assess in vivo hepatic fatty composition. In this study, we evaluate the use of the 2D Localized Correlation Spectroscopy (LCOSY) to analyze lipid composition of fatty liver of ob/ob mice and compare it to 1D MRS . Our results show that LCOSY can be used for the study of fatty liver to derive quantitative indexes in a more robust way than 1D MRS.

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