Abstract #2868
Influence of phospholipid enriched 19 F nanoparticles on fluorine uptake in dendritic cells
Stefano Lepore 1 , Karl Sydow 2 , Susanne Drechsler 1 , Min-Chi Ku 1 , Helmar Waiczies 1,3 , Conrad Martin 1 , Irene Schuetz 2 , Bettina Purfrst 4 , Margitta Dathe 2 , Thoralf Niendorf 1,5 , and Sonia Waiczies 1,5
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrck Center for Molecular Medicine, Berlin,
Berlin, Germany,
2
Department
of Medicinal Chemistry/Chemical Biology,
Leibniz-Institut fr Molekulare Pharmakologie, Berlin,
Berlin, Germany,
3
MRI.Tools
GmbH, Berlin, Berlin, Germany,
4
Electron
Microscopy, Max Delbrck Center for Molecular Medicine,
Berlin, Germany, Berlin, Berlin, Germany,
5
Experimental
and Clinical Research Center (ECRC), Berlin, Berlin,
Germany
Studying the migratory behavior of immune cells is
pivotal to better understand the development of
immune-mediated pathologies, It has been already
demonstrated that fluorine (
19
F) MRI enables
spatio-temporal tracking of dendritic cells (DC)
in
vivo
. The aim of this study is to overcome the
19
F
sensitivity barriers by increasing the uptake of
19
F
nanoparticles in DC. Therefore we explored the impact of
aminophospholipids incorporated into the
19
F
nanoparticle on uptake by DC and on labeling. We show
how this incorporation resulted in fluorine uptake
increase confirmed by
19
F
spectroscopy and microscopy, with minor changes in the
migration capability of DC.
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