Meeting Banner
Abstract #2862

Glucan Particles as a new platform for MRI visualization of inflammatory process

Francesca Garello 1 , Cristina Chirizzi 1 , Francesca Arena 2 , Sara Figueiredo 3 , Daniela Delli Castelli 1 , Valeria Menchise 1 , Silvio Aime 1,2 , and Enzo Terreno 1,2

1 Molecular biotechnology and health sciences, University of Torino, Torino, Torino, Italy, 2 Center for Preclinical Imaging, University of Torino, Colleretto Giacosa, Torino, Italy, 3 Department of Life Sciences, Faculty of Sciences and Technology, and Center for Neurosciences and Ce, University of Coimbra, Coimbra, Coimbra, Portugal

Glucan particles (GPs) could be considered innovative and biocompatible microcarriers. Their high affinity for Dectin-1 receptor, expressed on different phenotypes of immune system cells, makes them suitable for imaging inflammatory processes. In this work, GPs were efficiently loaded with either paramagnetic Gd-based compounds (for proton MRI) or perfluorocarbons (PFCs, for 19 F MRI). The carriers obtained showed very high values of relaxivity and fair fluorine payloads. The limit of sensitivity related to loaded GPs was explored both by 1 H and 19 F MRI. Moreover, J774.A1 macrophage incubation with loaded GPs and subsequent MRI of cells at 7 T were performed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here