Abstract #2861
Nano-thermometer with Thermo-sensitive Polymer Grafted USPIOs behaving as Positive Contrast Agents in low-field MRI
Sophie Laurent 1 , Adeline Hannecart 2 , Dimitri Stanicki 2 , Luce Vander Elst 2 , Sebastien Boutry 3 , Sebastien Lecommandoux 4 , Julie Thvenot 4 , Colin Bonduelle 4 , Aurlien Trotier 5 , Philippe Massot 5 , Sylvain Miraux 5 , Olivier Sandre 4 , and Robert N Muller 2,3
1
General, Organic and Biomedical Chemistry,
NMR and Molecular Imaging Laboratory, UMONS, Mons,
Hainaut, Belgium,
2
General,
Organic and Biomedical Chemistry, NMR and Molecular
Imaging Laboratory, UMONS, Hainaut, Belgium,
3
Center
for Microscopy and Molecular Imaging, Hainaut, Belgium,
4
Laboratoire
de Chimie des Polymres Organiques, Universit de
Bordeaux, France,
5
Rsonance
Magntique des Systmes Biologiques, Universit de
Bordeaux, France
Jeffamine M-2005 (PEO5-st-PPO37) was grafted onto
USPIO. The resulting polymer-nanosystem exhibits a
temperature-responsive colloidal behaviour, the surface
reversibly changing from hydrophilic below LCST to
hydrophobic above it. This phenomenon was utilized to
design thermo-sensitive contrast agents for MRI. To
illustrate the interest of such polymer-coated USPIO for
MRI thermometry, sample tubes were imaged on low-field
(8.25 MHz) and high-field (300 MHz) MRI scanners with
either T1- or T2*-weighted spin echo sequences. The
positive contrast on low-field MR images and the
linearity of the signal with a T2*-weighted sequence
over the whole temperature range 15C 50C renders
these polymer-USPIO interesting positive contrast
agents, also working as nano-thermometers.
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