Meeting Banner
Abstract #2844

nanoPARCEL probe : soft nanoparticles containing MRI and fluorescence imaging probes

Shuhei Murayama 1,2 , Jun-ichiro Jo 1 , Yuka Shibata 2 , Kun Liang 3 , Tomofumi Santa 2 , Tsuneo Saga 1 , Ichio Aoki 1 , and Masaru Kato 2

1 Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, 2 Graduate School of Pharmaceutical Sciences and GPLLI Program, The University of Tokyo, Tokyo, Tokyo, Japan, 3 Center for Medical Systems Innovation Summer Internship Program, The University of Tokyo, Tokyo, Tokyo, Japan

We developed a simple method to prepare PEG-based soft nanoparticles that encapsulate dual imaging probes. The nanoparticles were administrated to mice and the pharmacokinetics of the nanoparticles was analyzed by means of MRI, fluorescence spectroscopy, and transmission electron microscopy. The soft nanoparticles were excreted by the mice rapidly through the urine without collapse and without leaking of the probe. The pharmacokinetics of the nanoparticles was not changed by the encapsulated molecules and acute toxicity to mice was negligible. It was expect that these PEG-based soft nanoparticles will be applicable for use as a safe diagnostic agent.

This abstract and the presentation materials are available to members only; a login is required.

Join Here