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Abstract #2842

MRI of myocardial infarction with Vasovist: A potential marker for permeability in MI

Andrea Protti 1 , Xuebin Dong 1 , Silvia Lorrio 2 , Alkystis Phinikaridou 2 , Begona Lavin 2 , Ajay Shah 1 , and Rene Botnar 2

1 Kings College London British Heart Foundation Centre of Excellence, London, UK, United Kingdom, 2 King's College London, London, UK, United Kingdom

Introduction. The pathophysiological and molecular mechanisms of cardiac remodeling after the onset of MI have been widely studied with histochemistry techniques [1] and imaging techniques such as echocardiography [2] and MRI. Such studies suggest a degradation of the matrix leading to creation of a collagen-based scar with some elastin content. Elastin is important because it may provide a degree of elasticity to the infarcted tissue thus decreasing the risk of myocardial rupture. In this study, we investigated the elastin content of the infarcted myocardium in a mouse model using MRI after injection of the ESMA contrast agent. Areas of uptake and relaxation values over a longitudinal study were estimated.

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