Abstract #2818
Monitoring the Accumulation of Natural Fruit-derived diaCEST Liposomes in B16 Melanoma
Xiaolei Song 1,2 , Tao Yu 1,3 , Deepak Kadayakkara 1 , Kannie W Y Chan 1,2 , Yuan Qiao 4 , Jeff W M Bulte 1,2 , Peter CM van Zijl 1,2 , Justin S Hanes 3 , and Michael T McMahon 1,2
1
Division of MR Research, The Russell H.
Morgan Department of Radiology and Radiological Science,
The Johns Hopkins University, Baltimore, Maryland,
United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Center
for Nanomedicine, The Johns Hopkins University,
Baltimore, Maryland, United States,
4
The
Ludwig Center for Cancer Genetics and Therapeutics,
Howard Hughes Medical Institute and Sidney Kimmel Cancer
Center at Johns Hopkins Medical Institute, Maryland,
United States
Nanocarriers designed for imaging are becoming a
powerful tool in oncology, allowing not only tumor
detection but also assessment of tumor blood vessel
permeability. Liposomes loaded with non-metallic diaCEST
MR agents enable evaluation of the efficacy of tumor
targeting. Recently a new family of CEST agents was
reported, i.e., salicylic acid (SA) and analogues, which
contain labile protons with large resonance shifts from
water. We developed a series of SA-analogue liposomes
for CEST MRI. Of these, 2,4-Dihydroxybenzoic acid, a
fruit metabolite, showed the best liposomal retention
(>40%) in vitro and also in vivo in mice bearing B16
melanomas, namely 3% CEST contrast.
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