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Abstract #2806

Enhanced contrast of punctuate paramagnetic structures through zero-padding

Clemens Diwoky 1 , Daniel Liebmann 2 , Dirk Strunk 3 , and Rudolf Stollberger 1

1 Graz University of Technology, Graz, Austria, 2 Stem Cell Research Unit, Dept. of Hematology, Univ. Clinic of Internal Medicine, Medical University of Graz, Graz, Austria, 3 Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria

Within this study we show that for punctuate paramagnetic structures the positioning of the perturber relative to the imaging sampling grid has a notable impact on the signal decrease of the acquired voxel. This effect can be employed in order to boost the contrast of labelled cells if the underlying 3D GRE dataset is zeropadded and a minimum intensity projection between the sub-voxel sampling points is calculated. Simulations and in-vitro cell phantom experiments are used to confirm our theory. The results show a remarkable gain in negative contrast for iron-oxide labelled cells.

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