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Abstract #2801

Detection of prostate tumor metabolism using hyperpolarized [1-13C]-acetate

Concetta Valeria Gringeri 1 , Ulrich Koellisch 2,3 , Annette Frank 4 , Rolf Schulte 3 , Axel Haase 2 , Markus Schwaiger 4 , and Marion Irene Menzel 3

1 Institute of Nuclear Medicine, Klinikum rechts der Isar, TUM, Munich, Bayern, Germany, 2 IMETUM, TUM, Munich, Bayern, Germany, 3 GE Global Research, Munich, Bayern, Germany, 4 Institute of Nulcear Medicine, Klinikum rechts der Isar, TUM, Munich, Bayern, Germany

Prostate cancer is the most common cancer in the elderly men and the second leading cause of cancer death in men. Prostate tumor as well as other cancers is characterized by altered energy metabolism and up-regulation of fatty acid synthesis. Hyperpolarized 13C-acetate can be used to investigate prostate tumor metabolism through measurement of the tracer uptake and the metabolic conversion to Acetyl-carnitine (ALCAR) by developing a SNR optimal pulse sequence. An increase by time of acetate uptake was detected in the tumor region allowing to define the time evolution of the signal in tumor and blood vessels. This study reveals that the visualization of prostate cancer with HP 13C-acetate is feasible in rats. Such baseline data could be important when following the modifications in metabolism and to monitor FAS expression in prostate cancer. Further investigations have to be done to evaluate the possibility to correlate cancer aggressiveness with quantitative analysis of prostate cancer metabolism and HP 13C-acetate tumor uptake.

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