Abstract #2801
Detection of prostate tumor metabolism using hyperpolarized [1-13C]-acetate
Concetta Valeria Gringeri 1 , Ulrich Koellisch 2,3 , Annette Frank 4 , Rolf Schulte 3 , Axel Haase 2 , Markus Schwaiger 4 , and Marion Irene Menzel 3
1
Institute of Nuclear Medicine, Klinikum
rechts der Isar, TUM, Munich, Bayern, Germany,
2
IMETUM,
TUM, Munich, Bayern, Germany,
3
GE
Global Research, Munich, Bayern, Germany,
4
Institute
of Nulcear Medicine, Klinikum rechts der Isar, TUM,
Munich, Bayern, Germany
Prostate cancer is the most common cancer in the elderly
men and the second leading cause of cancer death in men.
Prostate tumor as well as other cancers is characterized
by altered energy metabolism and up-regulation of fatty
acid synthesis. Hyperpolarized 13C-acetate can be used
to investigate prostate tumor metabolism through
measurement of the tracer uptake and the metabolic
conversion to Acetyl-carnitine (ALCAR) by developing a
SNR optimal pulse sequence. An increase by time of
acetate uptake was detected in the tumor region allowing
to define the time evolution of the signal in tumor and
blood vessels. This study reveals that the visualization
of prostate cancer with HP 13C-acetate is feasible in
rats. Such baseline data could be important when
following the modifications in metabolism and to monitor
FAS expression in prostate cancer. Further
investigations have to be done to evaluate the
possibility to correlate cancer aggressiveness with
quantitative analysis of prostate cancer metabolism and
HP 13C-acetate tumor uptake.
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