Abstract #2799
SNR comparison between CSI and spectral-spatial EPI acquisitions for hyperpolarized 13C metabolic imaging
Albert P Chen 1 and Charles H Cunningham 2,3
1
GE Healthcare, Toronto, ON, Canada,
2
Imaging
Research, Sunnybrook Health Sciences Centre, Toronto,
ON, Canada,
3
Deptartment
of Medical Biophysics, University of Toronto, Toronto,
ON, Canada
In the first in human hyperpolarized 13C metabolic
imaging study in prostate cancer patients, spectroscopic
based chemical shift imaging technique was utilized to
acquire spatially localized hyperpolarized [1-13C]
pyruvate and [1-13C]lactate images from a single imaging
window. Imaging based approaches utilizing selective
excitation of a specific metabolite has been developed
in recent years to enable acquisition of temporally
resolved 13C metabolic imaging data throughout the time
course of substrate infusion and its metabolic
conversions. In this study, a comparison between a
spectral-spatial EPI sequence designed for dynamic
hyperpolarized 13C metabolic imaging and the standard
CSI technique was performed in vivo.
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