Abstract #2787
Improved throughput of hyperpolarized substrates by 1H 13C cross-polarization DNP
Sami Jannin 1,2 , Aurlien Bornet 1 , Jonas Milani 1 , Basile Vuichoud 1 , Roberto Melzi 3 , Angel J. Perez Linde 1 , Patrick Hautle 4 , Ben van den Brandt 4 , Joost Lohman 5 , and Geoffrey Bodenhausen 1,6
1
EPFL, Lausanne, Vaud, Switzerland,
2
Bruker
BioSpin AG, Fallanden, Zurich, Switzerland,
3
Bruker
Italia, Milano, Italy,
4
PSI,
Villigen, Switzerland,
5
Bruker
UK Limited, Coventry, United Kingdom,
6
Dpartement
de Chimie, ENS, Paris, France
We show an efficient route for rapidly generating 13C
hyperpolarization on molecules such as pyruvate at
polarization levels exceeding P(13C)>40% in less than 30
minutes. The method begins by the rapid and efficient
hyperpolarization of 1H spins (P(1H)>80% in less than 5
minutes) at low temperature and high field (T = 1.2 K
and B0 = 6.7 T) using the inexpensive polarizing agent
TEMPOL, in combination with rapid 1H→13C polarization
transfer by cross-polarization (CP) at low temperature
in typically less than 2 ms.
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