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Abstract #2786

Chemical Shift Enhanced Acquisition of in vivo Hyperpolarized 13C Metabolism in 9.4T

Seungwook Yang 1 , Joonsung Lee 2,3 , Eunhae Joe 1 , Hansol Lee 1 , Young-Suk Choi 4 , Ho-Taek Song 4 , and Dong-Hyun Kim 1

1 Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, 2 Nano-Medical National Core Research Center, Yonsei University, Seoul, Korea, 3 SIRIC, Yonsei, Seoul, Korea, 4 Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea

A method for frequency-selective, high-resolution acquisition of hyperpolarized substrate and its downstream metabolites in vivo in 9.4T is presented. The spatial displacement caused by the chemical shift is utilized in the acquisition of metabolite-selective images by modifying the slice-selection gradients duration and polarity. By doing so, spectral bands of neighboring resonances can be pushed outside the subject while acquisition is done in a frequency-interleaved manner. In this work, a simple implementation of this concept into a conventional 3D CSI sequence is presented, along with initial application results from in vivo mouse kidney experiment in 9.4T.

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