Meeting Banner
Abstract #2782

Determination of Diffusive and Transport Processes of Hyperpolarized [1,1,2,2-D 4 , 1- 13 C]-Choline in the Rat Kidney

Trevor P. Wade 1,2 , Lanette Friesen-Waldner 2 , Curtis N. Wiens 3 , Kevin J. Sinclair 2 , Rachel Katz-Brull 4,5 , and Charles A. McKenzie 1,2

1 Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada, 2 Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Radiology, University of Wisconsin, Madison, WI, United States, 4 Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 5 BrainWatch Ltd., Tel-Aviv, Israel

Choline is important in cellular membrane construction, so there is interest in developing an MRI choline molecular probe. This study determined if uptake of hyperpolarized [1,1,2,2-D 4 , 1- 13 C]-Choline (CMP1) in rat kidneys is due to a saturable cellular transport process or an extracellular diffusion process. Dynamic, 1D images of rat kidneys were obtained after injection of four different doses of CMP1. If CMP1 uptake in kidneys was due solely to diffusion, the kidney signal would increase linearly with concentration. Instead, it began to plateau. This implies a saturable transport process occurs, and uptake is not limited to diffusion.

This abstract and the presentation materials are available to members only; a login is required.

Join Here