Abstract #2781
PHIP of valproic acid and related structures
Thomas Trantzschel 1 , Denise Lego 2 , Markus Plaumann 1 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , Gerd Buntkowsky 3 , Johannes Bernarding 1 , and Ute Bommerich 2
1
Department for Biometry and Medical
Informatics, Otto-von-Guericke Univeritt Magdeburg,
Magdeburg, Germany,
2
Leibniz
Institute for Neurobiology, Magdeburg, Germany,
3
Eduard-Zintl-Institute
for Inorganic Chemistry, Technical University Darmstadt,
Darmstadt, Germany,
4
Institute
of Physical and Theoretical Chemistry, Bonn, Germany
Parahydrogen Induced Polarization (PHIP) is increasingly
used as a promising tool for medical/biological
applications in magnetic resonance as it can increase
MR-sensitivity by orders of magnitude. So far only a few
number of molecules acting as metabolic sensors were
already hyperpolarized with PHIP, but the direct
hyperpolarization of drugs used in the treatment of
neurological disorders was not achieved so far. In this
study the feasibility of applying PHIP to valproate
(used in epilepsy treatment) and structurally related
molecules with different side chains was examined in NMR
and MRI experiments.
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