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Abstract #2725

Repeatability and Variability of Pre-Clinical Hepatic Arterial Spin Labelling

Rajiv Ramasawmy 1,2 , Adrienne E. Campbell-Washburn 3 , Sean Peter Johnson 1 , Jack Anthony Wells 1 , Rosamund Barbara Pedley 2 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1

1 Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom, 2 Cancer Institute, University College London, London, Greater London, United Kingdom, 3 National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Hepatic ASL (hASL) is an emerging area of research interest. We present repeatability and variability analysis of a respiratory-triggered flow-sensitive alternating inversion recovery (FAIR) Look-Locker arterial spin labelling (ASL) technique to measure mouse liver perfusion. To evaluate the liver ASL technique, repeatability and variability statistics were produced for repeat measurements within a single imaging session and between imaging sessions separated by one week. We show that the repeatability of the technique is potentially sufficient to allow longitudinal monitoring of pre-clinical liver perfusion in models of diseases such as cancer and cirrhosis.

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