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Abstract #2724

A Reproducibility Study of Arterial Spin Labeling based Glomerular Filtration Rate Estimate

BIN CHEN 1 , Hao Li 1 , Ya Cao 1 , Chengyan Wang 1 , Xiaoying Wang 1,2 , JUE ZHANG 1,3 , and Jing Fang 1,3

1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, Beijing, China, 2 Radiology, Peking University First Hospital, Beijing, Beijing, China, 3 College of Engineering, Peking University, Beijing, Beijing, China

Glomerular filtration rate (GFR) measurements have been studied with various kinetic models, however, all these techniques are based on gadolinium contrast agent. Arterial blood spin labeling MR imaging uses the water spins of blood as an endogenous tracer, therefore it is completely noninvasive. In this study, we aimed to investigate the variable-TE based FAIR-ASL technique in measuring GFR in human kidneys. Volunteer experiments show good reproducibility of the established method in renal function estimation.

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