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Abstract #2701

Improving perfusion quantification in Arterial Spin Labeling for delayed arrival times by using optimized acquisition schemes

Johanna Kramme 1 , Johannes Gregori 2 , Volker Diehl 1,3 , Vince Istvan Madai 4,5 , Federico C von Samson-Himmelstjerna 1,4 , Markus Lentschig 3 , Jan Sobesky 4,5 , and Matthias Gnther 1,6

1 Fraunhofer MEVIS, Bremen, Bremen, Germany, 2 Mediri GmbH, Heidelberg, Germany, 3 ZEMODI, Bremen, Germany, 4 Center for Stroke Research Berlin, Charit Universittsmedizin, Berlin, Germany, 5 Department of Neurology, Charit Universittsmedizin, Berlin, Germany, 6 University of Bremen, Bremen, Germany

SNR loss due to T1 decay at long TIs can be partly compensated by redistributing the acquisition schemes, resulting in improved perfusion quantification especially for patients with prolonged BATs. Varies redistribution schemes are presented where the number of averages is reduced at short TIs and increased at long once. The impact of the redistribution on perfusion estimation in cases of long BAT is studied and compared to the standard acquisition method. Such a correction is of high clinical relevance in cerebrovascular diseases or elderly patients showing prolonged BAT, as demonstrated in patients and in comparison to volunteers.

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