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Abstract #2699

Whole-brain High-resolution ASL at 3T

Marta Vidorreta 1 , Evelyne Balteau 2 , Ze Wang 3,4 , Enrico De Vita 5,6 , David L. Thomas 5 , John A. Detre 4,7 , and Mara A. Fernndez-Seara 1

1 Functional Neuroimaging Laboratory, CIMA, University of Navarra, Pamplona, Navarra, Spain, 2 Cyclotron Research Centre, University of Liege, Liege, Belgium, 3 Department of Phsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 4 Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 5 Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 6 Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 7 Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Recent technical developments have significantly increased the SNR of ASL perfusion MRI. Despite this, typical ASL acquisitions still employ large voxel sizes. Here, we implemented two optimized ASL sequences that allow whole-brain high-SNR high-resolution ASL acquisitions without increasing scanning duration, featuring pseudo-continuous labeling and segmented 3D readouts with background suppression. Two readout schemes were tested, with Cartesian and spiral-based in-plane trajectories. Perfusion maps were acquired in 15 volunteers with resolution 2x2x4mm3, and quality was assessed via SNR and GM-WM contrast. The spiral-based readout yielded higher SNR due to its inherent central k-space oversampling, and shorter effective TE and readout time.

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