Abstract #2699
Whole-brain High-resolution ASL at 3T
Marta Vidorreta 1 , Evelyne Balteau 2 , Ze Wang 3,4 , Enrico De Vita 5,6 , David L. Thomas 5 , John A. Detre 4,7 , and Mara A. Fernndez-Seara 1
1
Functional Neuroimaging Laboratory, CIMA,
University of Navarra, Pamplona, Navarra, Spain,
2
Cyclotron
Research Centre, University of Liege, Liege, Belgium,
3
Department
of Phsychiatry, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
4
Department
of Radiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States,
5
Academic
Neuroradiological Unit, Department of Brain Repair and
Rehabilitation, UCL Institute of Neurology, London,
United Kingdom,
6
Lysholm Department of
Neuroradiology, National Hospital for Neurology and
Neurosurgery, London, United Kingdom,
7
Department
of Neurology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States
Recent technical developments have significantly
increased the SNR of ASL perfusion MRI. Despite this,
typical ASL acquisitions still employ large voxel sizes.
Here, we implemented two optimized ASL sequences that
allow whole-brain high-SNR high-resolution ASL
acquisitions without increasing scanning duration,
featuring pseudo-continuous labeling and segmented 3D
readouts with background suppression. Two readout
schemes were tested, with Cartesian and spiral-based
in-plane trajectories. Perfusion maps were acquired in
15 volunteers with resolution 2x2x4mm3, and quality was
assessed via SNR and GM-WM contrast. The spiral-based
readout yielded higher SNR due to its inherent central
k-space oversampling, and shorter effective TE and
readout time.
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