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Abstract #2685

Assessment of white matter tract integrity metrics in cuprizone-induced white matter degeneration with diffusion MRI

Magdalena Zurek 1 , Kerryanne Winters 1 , Jin Zhang 1 , Joe Rodriguez 1 , Dmitry S. Novikov 1 , Sungheon Kim 1 , and Els Fieremans 1

1 Department of Radiology, New York University School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, New York, United States

We assessed diffusion white matter tract integrity (WMTI) metrics, in particular tortuosity and axonal water fraction (AWF), in an experimental model of cuprizone-induced WM degeneration, against conventional MRI myelin indicators and histopathology. DTI, WMTI metrics, and traditional MR myelin estimators such as T2 and MTR were sensitive to the effect of the cuprizone treatment, however the overall comparison between new and conventional parameters showed that tortuosity, and AWF were the most sensitive measures for cuprizone-induced changes. Our primarily results indicate that WMTI imaging markers can be valuable in assessing WM degeneration.

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