Abstract #2685
Assessment of white matter tract integrity metrics in cuprizone-induced white matter degeneration with diffusion MRI
Magdalena Zurek 1 , Kerryanne Winters 1 , Jin Zhang 1 , Joe Rodriguez 1 , Dmitry S. Novikov 1 , Sungheon Kim 1 , and Els Fieremans 1
1
Department of Radiology, New York University
School of Medicine, Bernard and Irene Schwartz Center
for Biomedical Imaging, New York, New York, United
States
We assessed diffusion white matter tract integrity (WMTI)
metrics, in particular tortuosity and axonal water
fraction (AWF), in an experimental model of cuprizone-induced
WM degeneration, against conventional MRI myelin
indicators and histopathology. DTI, WMTI metrics, and
traditional MR myelin estimators such as T2 and MTR were
sensitive to the effect of the cuprizone treatment,
however the overall comparison between new and
conventional parameters showed that tortuosity, and AWF
were the most sensitive measures for cuprizone-induced
changes. Our primarily results indicate that WMTI
imaging markers can be valuable in assessing WM
degeneration.
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