Abstract #2683
Leukoencephalopathy in acute CO intoxication: Diffusion kurtosis versus diffusivity
Ping-Huei Tsai 1,2 , Ming-Chung Chou 3 , Cheng-Yu Chen 1,2 , Shih-Wei Chiang 4,5 , Chao-Ying Wang 5 , Hsiao-Wen Chung 4 , Hung-Wen Kao 5 , and Yi-Hsiu Hsiao 1
1
Imaging Research Center, Taipei Medical
University, Taipei, Taiwan,
2
Department
of Medical Imaging, Taipei Medical University Hospital,
Taipei Medical University, Taipei, Taiwan,
3
Department
of Medical Imaging and Radiological Sciences, Kaohsiung
Medical University, Kaohsiung, Taiwan,
4
Graduate
Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan,
5
Department
of Radiology, Tri-Service General Hospital, National
Defense Medical Center, Taipei, Taiwan
Acute CO intoxication is one of the most common lethal
poisons worldwide, and could lead to brain injury
resulting from leukoencephalopathy. Although diffusion
tenor (DT) related parametric maps could help assess the
brain structural changes resulting from demyelination,
it may not be highly sensitive to observe the subtle
alternations in patients with acute CO intoxication. The
purpose of this study is to validate evaluate the
ability of diffusion kurtosis imaging (DKI) for early
detection of the brain WM microstructural changes. The
present finding indicated that the use of DKI method may
provide some valuable information in prediction of
leukoencephalopathy in these patients.
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