Abstract #2661
Anisotropy, Compartmentalization, and Anomalous Diffusion of Intracellular Metabolites in the Axons and Glia of the Human Brain at 7T
Carson Ingo 1 , Itamar Ronen 1 , and Andrew G. Webb 1
1
C. J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center, Leiden, Netherlands
Recently, there was the first report of anomalous
diffusion in DWS measurements of intracellular
metabolites in the rat brain at 7T utilizing ultra-short
diffusion times afforded by oscillating gradients. Here,
we consider in vivo measurements of anomalous diffusion
for tNAA, tCho, and tCr in the human brain at 7T with
conventional diffusion times. Our study suggests for
metabolites: 1) white matter anisotropy does not
contribute to Gaussian or anomalous diffusion patterns,
2) compartmental distribution does not necessarily
contribute to anomalous diffusion, and 3) the unique
sub-diffusive behavior of tCr may be influenced by other
factors like chemical exchange.
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